LIMITED CAPACITY FOR TOLERIZATION OF CD4(+) T-CELLS SPECIFIC FOR A PANCREATIC BETA-CELL NEO-ANTIGEN

被引：105

作者：

FORSTER, I

HIROSE, R

ARBEIT, JM

CLAUSEN, BE

HANAHAN, D

机构：

[1] UNIV COLOGNE, INST GENET, D-50931 COLOGNE, GERMANY

[2] UNIV CALIF SAN FRANCISCO, DEPT BIOCHEM & BIOPHYS, SAN FRANCISCO, CA 94143 USA

[3] UNIV CALIF SAN FRANCISCO, HORMONE RES INST, SAN FRANCISCO, CA 94143 USA

来源：

IMMUNITY | 1995年 / 2卷 / 06期

关键词：

D O I：

10.1016/1074-7613(95)90002-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice transgenic for SV40 T antigen (Tag) under control of the rat insulin promoter (RIP) develop two alternative immunological phenotypes: tolerance or autoimmunity towards Tag. We utilized the T cell receptor (TCR) genes expressed in a Tag-specific CD4+ cell from an autoimmune RIP-Tag mouse to generate two lines of TCR transgenic mice in which either 10% or 90% of peripheral T cells express the transgenic TCR. Where cross-bred to the tolerant RIP1-Tag2 line, mice from the low frequency TCR line showed partial deletion of peripheral Tag-specific T cells and nonresponsiveness of those that remained. In contrast, crossbred mice in which transgenic T cells comprised a majority of the T cell population were nontolerant both in vivo and in vitro. Thus, tolerization of CD4+ T cells specific fora rare self-antigen may fail if too many autoreactive T cells develop.

引用

页码：573 / 585

页数：13

共 58 条

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