THE PURINE 2-AMINO GROUP AS A CRITICAL RECOGNITION ELEMENT FOR BINDING OF SMALL MOLECULES TO DNA

被引：46

作者：

WARING, MJ ^{[1
]}

BAILLY, CB ^{[1
]}

机构：

[1] INST RECH CANC,INSERM,U124,F-59045 LILLE,FRANCE

来源：

GENE | 1994年 / 149卷 / 01期

基金：

英国惠康基金;

关键词：

DNA RECOGNITION; FOOTPRINTING; ECHINOMYCIN; ACTINOMYCIN; NETROPSIN;

D O I：

10.1016/0378-1119(94)90414-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The expedient of preparing homologous DNA samples substituted with I for G, DAP for A, or both, has been used to investigate the role of the purine 2-amino group in determining the preferred binding sites for antibiotics on DNA. The selectivity of echinomycin for CpG steps, of actinomycin for GpC steps, and of netropsin for A + T-rich tracts, is seen to be radically altered in the substituted DNA molecules.

引用

收藏

页码：69 / 79

页数：11

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