HUMAN PAPILLOMAVIRUS AND DISEASE-FREE SURVIVAL IN FIGO STAGE IB CERVICAL-CANCER

被引:46
作者
UNGER, ER
VERNON, SD
THOMS, WW
NISENBAUM, R
SPANN, CO
HOROWITZ, IR
ICENOGLE, JP
REEVES, WC
机构
[1] EMORY UNIV, SCH MED, DEPT RADIAT ONCOL, ATLANTA, GA USA
[2] EMORY UNIV, SCH MED, DEPT OBSTET & GYNECOL, ATLANTA, GA USA
[3] KLEMM ANAL GRP, ATLANTA, GA USA
[4] CTR DIS CONTROL & PREVENT, NATL CTR INFECT DIS, VIRAL EXANTHEMS & HERPESVIRUS BRANCH, ATLANTA, GA 30341 USA
关键词
D O I
10.1093/infdis/172.5.1184
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine if human papillomavirus (HPV) in the primary tumor was associated with disease free survival of stage Ib cervical cancer patients, archival tissues from 47 patients were analyzed for HPV DNA by in situ hybridization (ISH) and polymerase chain reaction. HPV integration was determined by ISH signal pattern. Laboratory data were correlated with clinical parameters and disease-free survival. Kaplan-Meier estimates of 4-year disease-free survival were 56% in women with HPV detected in the primary tumor by ISH and 100% for women in whom HPV was not detected (P = .02). Four-year disease-free survival was 39% for patients with integrated HPV in the primary tumor (P = .005 vs. HPV-negative tumors and .05 vs. HPV episomal or episomal/integrated). HPV detection and integration state was not associated with any other clinical variable. Detection of integrated HPV DNA in the primary tumor was strongly associated with treatment failure.
引用
收藏
页码:1184 / 1190
页数:7
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