PANCREATIC-CANCER AND THE FAMILIAL ATYPICAL MULTIPLE MOLE MELANOMA (FAMMM) SYNDROME

被引：77

作者：

LYNCH, HT

FUSARO, RM

机构：

[1] Department of Preventive Medicine/Public Health, Creighton University School of Medicine, Omaha, NE

[2] Department of Medicine-Dermatology, Creighton University School of Medicine, Omaha, NE

[3] Department of Medicine-Dermatology, University of Nebraska Medical Center, Omaha, NE

来源：

PANCREAS | 1991年 / 6卷 / 02期

关键词：

PANCREATIC CANCER; GENETICS; MALIGNANT MELANOMA; FAMMM;

D O I：

10.1097/00006676-199103000-00001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The role of host factors in the etiology of pancreatic cancer has received a paucity of systematic investigation. Anecdotal reports and one population-based study have supported the concept that familial clustering of this disease exists. We have studied a kindred with a cancer-associated genodermatosis known as familial atypical multiple mole melanoma (FAMMM) syndrome (hereditary dysplastic nevus syndrome). Three key relatives have manifested pancreatic carcinoma. Since FAMMM may account for as much as 10% of the total malignant melanoma burden, its association with pancreatic cancer harbors important public health implications. Given the fact that the etiology of pancreatic cancer remains enigmatic, it is important to investigate all possible clues to its causality, including the potential role of host factors.

引用

页码：127 / 131

页数：5

共 28 条

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