DAILY VARIATION IN THE CONCENTRATION OF MELATONIN AND 5-METHOXYTRYPTOPHOL IN THE HUMAN PINEAL-GLAND - EFFECT OF AGE AND ALZHEIMERS-DISEASE

被引：182

作者：

SKENE, DJ

VIVIENROELS, B

SPARKS, DL

HUNSAKER, JC

PEVET, P

RAVID, D

SWAAB, DF

机构：

[1] UNIV KENTUCKY,MED CTR,DEPT NEUROL,LEXINGTON,KY 40506

[2] UNIV KENTUCKY,MED CTR,DEPT PATHOL,LEXINGTON,KY 40506

[3] KENTUCKY STATE MED EXAMINERS PROGRAM,LEXINGTON,KY

[4] NETHERLANDS INST BRAIN RES,1095 KJ AMSTERDAM,NETHERLANDS

来源：

BRAIN RESEARCH | 1990年 / 528卷 / 01期

关键词：

5-Methoxytryptophol; Age; Alzheimer's disease; Daily rhythm; Human; Melatonin; Pineal gland;

D O I：

10.1016/0006-8993(90)90214-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years). © 1990.

引用

页码：170 / 174

页数：5

共 21 条

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