SPECIES-DIFFERENCES BETWEEN [H-3] SUBSTANCE-P BINDING IN RAT AND GUINEA-PIG SHOWN BY THE USE OF PEPTIDE AGONISTS AND ANTAGONISTS

被引：37

作者：

FARDIN, V

GARRET, C

机构：

[1] Rhone-Poulenc Rorer, Centre de Recherches de Vitiy-Alfortville, 94403 Vitry-sur-Seine Cédex, 13 Quai Jules Guesde

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 201卷 / 2-3期

关键词：

BRAIN (RAT); ILEUM (GUINEA-PIG); BRAIN (GUINEA-PIG); SUBSTANCE-P; TACHYKININ RECEPTORS;

D O I：

10.1016/0014-2999(91)90350-Y

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The affinities of various substance P agonists and antagonists for NK1 receptors in rat and guinea-pig tissues were compared. Striking species differences were observed. Both septide and [D-Pro4,D-Trp7,9]SP-(4-11) possessed much higher affinity for sites in the guinea-pig (brain and ileum) than for sites in the rat brain. These results could be explained by differences in the structure of the NK1 receptor according to the species, although the existence of various subtypes of NK1 binding sites in the two species cannot be excluded.

引用

页码：231 / 234

页数：4

共 11 条

[1] HIGH-AFFINITY H-3-SUBSTANCE-P BINDING TO LONGITUDINAL MUSCLE MEMBRANES OF THE GUINEA-PIG SMALL-INTESTINE [J].

BUCK, SH ;

MAURIN, Y ;

BURKS, TF ;

YAMAMURA, HI .

LIFE SCIENCES, 1984, 34 (05) :497-507

[2]

LAUFER R, 1988, J PHARMACOL EXP THER, V245, P639

[3] MULTIPLE TACHYKININ BINDING-SITES IN PERIPHERAL-TISSUES AND IN BRAIN [J].

LEE, CM ;

CAMPBELL, NJ ;

WILLIAMS, BJ ;

IVERSEN, LL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 130 (03) :209-217

[4] BINDING CHARACTERISTICS OF [I-125] BOLTON-HUNTER [SAR9,MET(O2)11]SUBSTANCE-P, A NEW SELECTIVE RADIOLIGAND FOR THE NK1 RECEPTOR [J].

LEW, R ;

GERAGHTY, DP ;

DRAPEAU, G ;

REGOLI, D ;

BURCHER, E .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 184 (01) :97-108

[5] FURTHER DEMONSTRATION THAT [PRO9]-SUBSTANCE-P IS A POTENT AND SELECTIVE LIGAND OF NK-1 TACHYKININ RECEPTORS [J].

PETITET, F ;

BEAUJOUAN, JC ;

SAFFROY, M ;

TORRENS, Y ;

CHASSAING, G ;

LAVIELLE, S ;

BESSEYRE, J ;

GARRET, C ;

CARRUETTE, A ;

GLOWINSKI, J .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (03) :879-889

[6] MULTIPLE TACHYKININ RECEPTORS IN GUINEA-PIG BRAIN - HIGH-DENSITIES OF SUBSTANCE-K (NEUROKININ-A) BINDING-SITES IN THE SUBSTANTIA NIGRA [J].

QUIRION, R ;

DAM, TV .

NEUROPEPTIDES, 1985, 6 (03) :191-204

[7] RECEPTORS FOR SUBSTANCE-P AND RELATED NEUROKININS [J].

REGOLI, D ;

DRAPEAU, G ;

DION, S ;

DORLEANSJUSTE, P .

PHARMACOLOGY, 1989, 38 (01) :1-15

[8] A POTENT NONPEPTIDE ANTAGONIST OF THE SUBSTANCE-P (NK1) RECEPTOR [J].

SNIDER, RM ;

CONSTANTINE, JW ;

LOWE, JA ;

LONGO, KP ;

LEBEL, WS ;

WOODY, HA ;

DROZDA, SE ;

DESAI, MC ;

VINICK, FJ ;

SPENCER, RW ;

HESS, HJ .

SCIENCE, 1991, 251 (4992) :435-437

[9] SPECIFIC BINDING OF A I-125-SUBSTANCE-P DERIVATIVE TO RAT-BRAIN SYNAPTOSOMES [J].

VIGER, A ;

BEAUJOUAN, JC ;

TORRENS, Y ;

GLOWINSKI, J .

JOURNAL OF NEUROCHEMISTRY, 1983, 40 (04) :1030-1039

[10] H-3-SUBSTANCE-P BINDING TO GUINEA-PIG ILEUM LONGITUDINAL SMOOTH-MUSCLE MEMBRANES [J].

WATSON, SP ;

IVERSEN, LL .

REGULATORY PEPTIDES, 1984, 8 (04) :273-281

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