THE ASSOCIATION OF AGE WITH GASTRIC-EMPTYING

被引：46

作者：

GAINSBOROUGH, N ^{[1
]}

MASKREY, VL ^{[1
]}

NELSON, ML ^{[1
]}

KEATING, J ^{[1
]}

SHERWOOD, RA ^{[1
]}

JACKSON, SHD ^{[1
]}

SWIFT, CG ^{[1
]}

机构：

[1] KINGS COLL,SCH MED & DENT,DEPT CLIN BIOCHEM,LONDON SE5,ENGLAND

来源：

AGE AND AGEING | 1993年 / 22卷 / 01期

关键词：

D O I：

10.1093/ageing/22.1.37

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.

引用

页码：37 / 40

页数：4

共 14 条

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