BIODISTRIBUTION OF AN ULTRASMALL SUPERPARAMAGNETIC IRON-OXIDE COLLOID, BMS-180549, BY DIFFERENT ROUTES OF ADMINISTRATION

被引：85

作者：

BENGELE, HH

PALMACCI, S

ROGERS, J

JUNG, CW

CRENSHAW, J

JOSEPHSON, L

机构：

[1] Advanced Magnetics Inc., Cambridge, MA 02138

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 03期

关键词：

LYMPHATIC; SUPERPARAMAGNETIC; CONTRAST AGENT;

D O I：

10.1016/0730-725X(94)92537-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The ultrasmall superparamagnetic iron oxide colloid BMS 180549 can be found in Lymph nodes by either subcutaneous (SC) or intravenous (IV) injection. With an SC injection in the front extremities, the axillary and brachial nodes attain the highest accumulations of the agent. With an SC injection in the rear extremities, the popliteal, iliac, and axillary nodes attain highest accumulations of the agent. With IV injection of the agent, the iliac, mediastinal and mesenteric nodes attain highest accumulations of the agent. Though the spleen is not involved with the drainage of the interstitial space near the site of SC injections, the mobility of BMS 180549 from such injection sites increases splenic relaxation rates. Based on a knowledge of the lymphatic system, a route of administration of BMS 180549 can be chosen to maximize the delivery of the agent to specific lymph nodes.

引用

页码：433 / 442

页数：10

共 20 条

[1]

Weissleder, Et al., Experimental lymph node metastases: Enhanced detection with MR lymphography, Radiology, 171, pp. 835-839, (1989)

[2]

Weissleder, Et al., Ultrasmall superparamagnetic iron oxide: An intravenous contrast agent for assessing lymph nodes with MR imaging, Radiology, 175, pp. 494-498, (1990)

[3]

Weissleder, Et al., Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging, Radiology, 175, pp. 489-493, (1990)

[4]

Josephson, Et al., A functionalized superparamagnetic iron oxide colloid as a receptor directed MR contrast agent, Magn. Reson. Imaging, 8, pp. 637-646, (1990)

[5]

Linder, Et al., The size and shape of heart and muscle ferritins analyzed by sedimentation, gel filtration, and electrophoresis, J. Biol. Chem., 256, pp. 9104-9110, (1981)

[6]

Shen, Et al., Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties, Magn. Reson. Med., 29, pp. 599-604, (1993)

[7]

Pouliquen, Et al., Investigation of the magnetic properties of iron oxide nanoparticles used as contrast agent for MRI, Magn. Reson. Med., 24, pp. 75-84, (1992)

[8]

Anai, Et al., Dextran-covered superparamagnetic iron oxide

[9]

assessment of cervical lymph nodes in humans, Book of abstracts: Eleventh Annual Meeting of the Society of Magnetic Resonance in Medicine, (1992)

[10]

Tilney, Patterns of lymphatic drainage in the rat, J. Anat., 109, pp. 369-383, (1971)

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