FUNCTIONALIZATION INCLUDING FLUORINATION OF CAFFEINE, GUANOSINE TETRAACETATE, AND URIDINE TRIACETATE USING ELECTROCHEMICAL OXIDATION

被引:39
作者
SONO, M
TOYODA, N
SHIZURI, Y
TORI, M
机构
[1] Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770, Yamashiro cho
关键词
D O I
10.1016/0040-4039(94)88476-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title compounds have been subjected to electrochemical oxidation with Et(3)N-3HF as an electrolyte. Caffeine afforded 8-fluorocaffeine as a sole product in 43% yield. Guanosine tetraacetate and uridine triacetate gave the fluorinated compounds in 7.3 and 4.8 % yield, respectively. Similar electrochemical oxidation of caffeine with methanol, KCl or KCN yielded 8-methoxycaffeine, 8-chloracaffeine, or 8-cyanocaffeine, respectively.
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页码:9237 / 9238
页数:2
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