FUNCTIONALIZATION INCLUDING FLUORINATION OF CAFFEINE, GUANOSINE TETRAACETATE, AND URIDINE TRIACETATE USING ELECTROCHEMICAL OXIDATION

被引：39

作者：

SONO, M

TOYODA, N

SHIZURI, Y

TORI, M

机构：

[1] Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770, Yamashiro cho

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 49期

关键词：

D O I：

10.1016/0040-4039(94)88476-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds have been subjected to electrochemical oxidation with Et(3)N-3HF as an electrolyte. Caffeine afforded 8-fluorocaffeine as a sole product in 43% yield. Guanosine tetraacetate and uridine triacetate gave the fluorinated compounds in 7.3 and 4.8 % yield, respectively. Similar electrochemical oxidation of caffeine with methanol, KCl or KCN yielded 8-methoxycaffeine, 8-chloracaffeine, or 8-cyanocaffeine, respectively.

引用

页码：9237 / 9238

页数：2

共 10 条

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