SUBSTRATE, SUBSTRATE-ANALOG, AND INHIBITOR INTERACTIONS WITH THE FERROUS ACTIVE-SITE OF CATECHOL 2,3-DIOXYGENASE MONITORED THROUGH XAS STUDIES

被引：10

作者：

BERTINI, I

BRIGANTI, F

MANGANI, S

NOLTING, HF

SCOZZAFAVA, A

机构：

[1] UNIV FLORENCE, DIPARTIMENTO CHIM, I-50121 FLORENCE, ITALY

[2] UNIV SIENA, DIPARTIMENTO CHIM, I-53100 SIENA, ITALY

[3] DESY, EUROPEAN MOLEC BIOL LAB OUTSTN, W-2000 HAMBURG 52, GERMANY

来源：

FEBS LETTERS | 1994年 / 350卷 / 2-3期

关键词：

CATECHOL; DIOXYGENASE; EXAFS; EXTRADIOL CLEAVAGE; PSEUDOMONAS PUTIDA;

D O I：

10.1016/0014-5793(94)00771-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of catechol (substrate), 2-hydroxy-pyridine-N-oxide (substrate analogue), and 2-bromophenol (inhibitor) with the extradiol cleaving catechol-2,3-dioxygenase from Pseudomonas putida mt-2 have been monitored through X-ray absorption spectroscopy (XAS). The analysis of the data provides details about the mode of coordination of the substrate and of the inhibitors to the active site of the enzyme.

引用

页码：207 / 212

页数：6

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