MAJORANOLIDE - A DELTA-LACTONE FROM PERSEA-MAJOR

被引：11

作者：

MA, WW

ANDERSON, JE

CHANG, CJ

SMITH, DL

MCLAUGHLIN, JL

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 08期

关键词：

bark; brine shrimp lethality; human tumour cell cytotoxicity; inhibition of crown gall tumours; Lauraceae; majoranolide; majorenolide; majorynolide; Persea major; δ-lactone;

D O I：

10.1016/0031-9422(90)85218-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the ethanol extract of the bark of Persea major, an additional new bioactive δ-lactone, majoranolide, has been isolated and characterized. The absolute stereochemistries of majoranolide and two previously isolated δ-lactones, majorynolide and majorenolide, have been determined by Horeau's method and CD spectra. Brine shrimp lethality was used to guide the fractionation, and the new lactone is moderately cytotoxic and inhibits crown gall tumours on potato discs. © 1990.

引用

页码：2698 / 2699

页数：2

共 6 条

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[5] MAJORENOLIDE AND MAJORYNOLIDE - A NEW PAIR OF CYTOTOXIC AND PESTICIDAL ALKENE-ALKYNE DELTA-LACTONES FROM PERSEA-MAJOR [J].

MA, WW ;

ANDERSON, JE ;

CHANG, CJ ;

SMITH, DL ;

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[6] BRINE SHRIMP - A CONVENIENT GENERAL BIOASSAY FOR ACTIVE-PLANT CONSTITUENTS [J].

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MCLAUGHLIN, JL .

PLANTA MEDICA, 1982, 45 (01) :31-34

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