STUDIES ON THE SYNTHESIS OF STRYCHNOS INDOLE ALKALOIDS

被引：13

作者：

BOSCH, J

SALAS, M

AMAT, M

ALVAREZ, M

MORGO, I

ADROVER, B

机构：

[1] Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona

来源：

TETRAHEDRON | 1991年 / 47卷 / 28期

关键词：

INDOLE; STRYCHNOS ALKALOIDS; NUCLEOPHILIC ADDITION TO PYRIDINIUM SALTS;

D O I：

10.1016/S0040-4020(01)87138-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetracycles 3b-d, having the ABCD ring substructure of Strychnos alkaloids and a N(b)-(formylmethyl) substituent protected as an oxime or hydrazone derivative, have been prepared by nucleophilic addition of the enolate of indoleacetic ester 1 to pyridinium salts 2b-d followed by acid cyclization. The same one-pot, two-step sequence allowed the preparation of tetracycle 3f, which incorporates an alpha-methoxyacrylate chain at the piperidine beta-position.

引用

页码：5269 / 5276

页数：8

共 20 条

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