学术探索
学术期刊
新闻热点
数据分析
智能评审

SISTER-CHROMATID EXCHANGE AND CHROMOSOME-ABERRATIONS INDUCED BY PARACETAMOL INVIVO IN BONE-MARROW CELLS OF MICE

被引：21
作者：
GIRI, AK
SIVAM, SS
KHAN, KA
机构：
[1] Division of Toxicology, Central Drug Research Institute, Lucknow, 226001
来源：
MUTATION RESEARCH | 1992年 / 278卷 / 04期
关键词：
PARACETAMOL; CHROMOSOME ABERRATIONS; SISTER-CHROMATID EXCHANGE; BONE-MARROW CELLS; MOUSE; INVIVO TESTS;
D O I：
10.1016/S0165-1218(10)80004-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Sister-chromatid exchange (SCE) and chromosome aberrations (CA) induced by paracetamol (PC), a common analgesic, were studied in vivo on bone-marrow cells of mice. The trend tests for the evidence of dose-response effects for both SCE and CA were significant. The significant increase in SCE as well as CA induced by PC may be attributed to the fact that PC can induce genotoxicity through DNA damage. Thus, the present study indicates that PC was genotoxic in vivo in bone-marrow cells of mice.
引用
收藏
页码：253 / 258
页数：6
相关论文
共 32 条
[1]  
Abe S, 1982, SISTER CHROMATID EXC, P461
[2]  
ALBANO E, 1985, MOL PHARMACOL, V28, P306
[3]   PARACETAMOL-STIMULATED LIPID-PEROXIDATION IN ISOLATED RAT AND MOUSE HEPATOCYTES [J].
ALBANO, E ;
POLI, G ;
CHIARPOTTO, E ;
BIASI, F ;
DIANZANI, MU .
CHEMICO-BIOLOGICAL INTERACTIONS, 1983, 47 (03) :249-263
[4]   N-ACETYL-PARA-BENZOQUINONE IMINE - A CYTOCHROME-P-450-MEDIATED OXIDATION-PRODUCT OF ACETAMINOPHEN [J].
DAHLIN, DC ;
MIWA, GT ;
LU, AYH ;
NELSON, SD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1327-1331
[5]   GENOTOXICITY OF ANALGESIC COMPOUNDS ASSESSED BY AN INVITRO MICRONUCLEUS ASSAY [J].
DUNN, TL ;
GARDINER, RA ;
SEYMOUR, GJ ;
LAVIN, MF .
MUTATION RESEARCH, 1987, 189 (03) :299-306
[6]   GENOTOXICITY STUDIES WITH PARACETAMOL [J].
DYBING, E ;
HOLME, JA ;
GORDON, WP ;
SODERLUND, EJ ;
DAHLIN, DC ;
NELSON, SD .
MUTATION RESEARCH, 1984, 138 (01) :21-32
[7]   INDUCTION OF LIVER-CELL TUMORS IN IF MICE BY PARACETAMOL [J].
FLAKS, A ;
FLAKS, B .
CARCINOGENESIS, 1983, 4 (04) :363-368
[8]  
FLAKS B, 1985, ACTA PATH MICRO IM A, V93, P367
[9]   SISTER-CHROMATID EXCHANGE AND CHROMOSOME-ABERRATIONS FOR 4 ALIPHATIC EPOXIDES IN MICE [J].
GIRI, AK ;
MESSERLY, EA ;
SINSHEIMER, JE .
MUTATION RESEARCH, 1989, 224 (02) :253-261
[10]   SISTER CHROMATID EXCHANGE INDUCED BY METANIL-YELLOW AND NITRITE SINGLY AND IN COMBINATION INVIVO ON MICE [J].
GIRI, AK ;
TALUKDER, G ;
SHARMA, A .
CANCER LETTERS, 1986, 31 (03) :299-303
1234