THE CHEMOTHERAPY OF RODENT MALARIA .49. THE ACTIVITIES OF SOME SYNTHETIC 1,2,4-TRIOXANES AGAINST CHLOROQUINE-SENSITIVE AND CHLOROQUINE-RESISTANT PARASITES .2. STRUCTURE-ACTIVITY STUDIES ON CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES (FENOZANS) AGAINST DRUG-SENSITIVE AND DRUG-RESISTANT LINES OF PLASMODIUM-BERGHEI AND P-YOELII SSP NS INVIVO

被引：56

作者：

PETERS, W ^{[1
]}

ROBINSON, BL ^{[1
]}

ROSSITER, JC ^{[1
]}

MISRA, D ^{[1
]}

JEFFORD, CW ^{[1
]}

机构：

[1] UNIV GENEVA,DEPT ORGAN CHEM,CH-1211 GENEVA 4,SWITZERLAND

来源：

ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY | 1993年 / 87卷 / 01期

关键词：

D O I：

10.1080/00034983.1993.11812734

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The activity of 51 synthetic cis-fused cyclopenteno-1,2,4-trioxanes has been examined against drug-sensitive and chloroquine-resistant malaria parasites in vivo. Some of them display high levels of blood schizontocidal activity when administered orally or subcutaneously. They retain their activity against lines of parasites that are resistant to widely differing antimalarials such as 4-aminoquinolines, aminoalcohols, dihydrofolate reductase inhibitors and artemisinin. The most potent compound of the present series is cis-(±)-4a,7a-dihydro-6,7a-di(p-fiuorophenyl)spiro[cyciopentane-3,3'-7H -cyclopenta-1,2,4-trioxin], otherwise known as Fenozan-50F.

引用

页码：9 / 16

页数：8