BIOSYNTHETIC-STUDIES OF THE EUDISTOMINS IN THE TUNICATE EUDISTOMA-OLIVACEUM

被引：18

作者：

SHEN, GQ ^{[1
]}

BAKER, BJ ^{[1
]}

机构：

[1] FLORIDA INST TECHNOL,DEPT CHEM,MELBOURNE,FL 32901

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 08期

基金：

美国国家卫生研究院;

关键词：

TUNICATE; BETA-CARBOLINE; BIOSYNTHESIS; ANTIBIOTIC;

D O I：

10.1016/0040-4039(94)88007-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The origin of eudistomin I (2) in the Floridian tunicate Eudistoma olivaceum has been investigated by in vivo techniques. Tryptophan and proline are the primary precursors to this antibiotic agent, while trypamine serves as an intermediate.

引用

页码：1141 / 1144

页数：4

共 16 条

[1]

GARSON MJ, 1993, CHEM REV, V93, P1699, DOI 10.1021/cr00021a003

[2] INVIVO INCORPORATION OF C-14 PHENYLALANINE INTO ASCIDIAN TUNICHROME [J].

HE, X ;

KUSTIN, K ;

PARRY, DL ;

ROBINSON, WE ;

RUBERTO, G ;

NAKANISHI, K .

EXPERIENTIA, 1992, 48 (04) :367-371

[3]

HERBERT RB, 1989, BIOSYNTHESIS SECONDA, P164

[4] INTRAMOLECULAR PICTET-SPENGLER REACTION OF N-ALKOXYTRYPTAMINES .3. STEREOSELECTIVE SYNTHESIS OF (-)-DEBROMOEUDISTOMIN-L AND (-)-O-METHYLDEBROMOEUDISTOMIN-E AND THEIR STEREOISOMERS [J].

HERMKENS, PHH ;

VONMAARSEVEEN, JH ;

OTTENHEIJM, HCJ ;

KRUSE, CG ;

SCHEEREN, HW .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (13) :3998-4006

[5]

HINO T, 1989, CHEM PHARM BULL, V37, P2596

[6]

IRELAND CM, 1988, MEM CALIF ACAD SCI, V13, P41

[7] 3 NEW BETA-CARBOLINES FROM THE BERMUDIAN TUNICATE EUDISTOMA-OLIVACEUM [J].

KINZER, KF ;

CARDELLINA, JH .

TETRAHEDRON LETTERS, 1987, 28 (09) :925-926

[8]

KIRKUP MP, 1989, TETRAHEDRON LETT, P6809

[9] EUDISTOMINS A, D, G, H, I, J, M, N, O, P, AND Q, BROMO-BETA-CARBOLINES HYDROXY-BETA-CARBOLINES PYRROLYL-BETA-CARBOLINES AND 1-PYRROLINYL-BETA-CARBOLINES FROM THE ANTIVIRAL CARIBBEAN TUNICATE EUDISTOMA-OLIVACEUM [J].

KOBAYASHI, J ;

HARBOUR, GC ;

GILMORE, J ;

RINEHART, KL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (05) :1526-1528

[10] EUDISTOMIDIN-B, EUDISTOMIDIN-C, AND EUDISTOMIDIN-D - NOVEL ANTILEUKEMIC ALKALOIDS FROM THE OKINAWAN MARINE TUNICATE EUDISTOMA-GLAUCUS [J].

KOBAYASHI, J ;

CHENG, JF ;

OHTA, T ;

NOZOE, S ;

OHIZUMI, Y ;

SASAKI, T .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (11) :3666-3670

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