OSTEOSARCOMA IN SIBLINGS - A CASE-REPORT

被引：4

作者：

DANCKWERTH, F

WUISMAN, P

RITTER, J

BLASIUS, S

JURGENS, H

OZAKI, T

WINKELMANN, W

机构：

[1] UNIV MUNSTER, KINDERHEILKUNDE PADIATR HAMATOL ONKOL KLIN & POLI, D-48129 MUNICH, GERMANY

[2] UNIV MUNSTER, INST PATHOL, D-48129 MUNICH, GERMANY

来源：

KLINISCHE PADIATRIE | 1995年 / 207卷 / 05期

关键词：

D O I：

10.1055/s-2008-1046555

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

With a brother and sister, osteosarcoma developed at the age of 11 and 14 respectively. With both there was no previous retinoblastoma or other bone disease with a proclivity to develop osteosarcoma. We discuss possible explanations for familial aggregation of osteosarcoma, citing external or genetic factors. We suggest that it is the retinoblastoma gene RB and the tumor suppressor gene p53 which play an important part in the development of osteosarcoma.

引用

页码：298 / 301

页数：4

共 44 条

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