共 74 条
Factors associated with clopidogrel nonresponsiveness
被引:7
作者:

Momary, Kathryn M.
论文数: 0 引用数: 0
h-index: 0
机构:
Mercer Univ, Coll Pharm & Hlth Sci, Dept Pharm Practice, 3001 Mercer Univ Dr, Atlanta, GA 30341 USA Mercer Univ, Coll Pharm & Hlth Sci, Dept Pharm Practice, 3001 Mercer Univ Dr, Atlanta, GA 30341 USA

Dorsch, Michael P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan Hlth Syst, Dept Pharm Serv, Ann Arbor, MI USA
Univ Michigan, Coll Pharm, Dept Clin Social & Adm Sci, Ann Arbor, MI 48109 USA Mercer Univ, Coll Pharm & Hlth Sci, Dept Pharm Practice, 3001 Mercer Univ Dr, Atlanta, GA 30341 USA
机构:
[1] Mercer Univ, Coll Pharm & Hlth Sci, Dept Pharm Practice, 3001 Mercer Univ Dr, Atlanta, GA 30341 USA
[2] Univ Michigan Hlth Syst, Dept Pharm Serv, Ann Arbor, MI USA
[3] Univ Michigan, Coll Pharm, Dept Clin Social & Adm Sci, Ann Arbor, MI 48109 USA
关键词:
clopiodgrel;
CYP450;
drug interactions;
pharmacogenetics;
D O I:
10.2217/FCA.10.1
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Clopiodgrel therapy is the standard of care in patients with acute coronary syndrome and in those undergoing percutaneous coronary intervention. However, there is a significant amount of interindividual variability in clopidogrel responsiveness. Clopidogrel is a prodrug and requires metabolism via several CYP450 enzymes in order to exert its antiplatelet effects. Interference in these activation steps is the primary cause of clopidogrel nonresponsiveness. This review focuses on genetic polymorphisms in, and drug interactions with, the CYP450 enzymes that are associated with clopidogrel nonresponsiveness. In addition, clinical factors that effect clopidogrel responsiveness are also reviewed. Particular emphasis is placed on those factors that are not only associated with a change in clopidogrel pharmacokinetics or pharmacodynamics, but are also associated with an increased risk of adverse cardiovascular events. Currently, the majority of data assessing clopidogrel nonresponsiveness focus on genetic variation in CYP2C19 and drug interactions with proton pump inhibitors. However, genetic variation in other CYP450 enzymes, other drug interactions and clinical causes have been studied and are also reviewed here. It is important for healthcare practitioners to recognize all of the causes of clopidogrel nonresponsiveness, especially as novel antiplatelet alternatives become available.
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页码:195 / 210
页数:16
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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,
2006, 48 (02)
:298-304

Angiolillo, Dominick J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Bernardo, Esther
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Ramirez, Celia
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Costa, Marco A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Sabate, Manel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Jimenez-Quevedo, Pilar
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Hernandez, Rosana
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Moreno, Raul
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Escaned, Javier
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Alfonso, Fernando
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Banuelos, Camino
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Bass, Theodore A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Macaya, Carlos
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA

Fernandez-Ortiz, Antonio
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32209 USA
[10]
Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
[J].
Angiolillo, Dominick J.
;
Fernandez-Ortiz, Antonio
;
Bernardo, Esther
;
Ramirez, Celia
;
Cavallari, Ugo
;
Trabetti, Elisabetta
;
Sabate, Manel
;
Hernandez, Rosana
;
Moreno, Raul
;
Escaned, Javier
;
Alfonso, Fernando
;
Banuelos, Camino
;
Costa, Marco A.
;
Bass, Theodore A.
;
Pignatti, Pier Franco
;
Macaya, Carlos
.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,
2006, 26 (08)
:1895-1900

Angiolillo, Dominick J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Fernandez-Ortiz, Antonio
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Bernardo, Esther
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Ramirez, Celia
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Cavallari, Ugo
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Trabetti, Elisabetta
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Sabate, Manel
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Hernandez, Rosana
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Moreno, Raul
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Escaned, Javier
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Alfonso, Fernando
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Banuelos, Camino
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Costa, Marco A.
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h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Bass, Theodore A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Pignatti, Pier Franco
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA

Macaya, Carlos
论文数: 0 引用数: 0
h-index: 0
机构: Univ Florida, Div Cardiol, Jacksonville, FL 32208 USA