HUMAN GRANULOSA-CELLS CONTAIN INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN (IGF BP-1) MESSENGER-RNA

被引：46

作者：

KOISTINEN, R ^{[1
]}

SUIKKARI, AM ^{[1
]}

TIITINEN, A ^{[1
]}

KONTULA, K ^{[1
]}

SEPPALA, M ^{[1
]}

机构：

[1] UNIV HELSINKI,INST BIOTECHNOL,SF-00100 HELSINKI 10,FINLAND

来源：

CLINICAL ENDOCRINOLOGY | 1990年 / 32卷 / 05期

关键词：

D O I：

10.1111/j.1365-2265.1990.tb00907.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previous studies have demonstrated expression of insulin‐like growth factor‐binding protein (IGF BP‐1) in secretory and decidualized endometrium, in adult and fetal liver, and in HepG2 liver cancer cells. We have studied the expression of IGF BP‐1 in various types of ovarian neoplasias, normal ovary, and granulosa cells from hyperstimulated human ovarian follicles by RNA blot hybridization. A single 1.6 kb mRNA species, similar to that present in human decidua, was identified in poly(A)RNA‐containing preparations of granulosa cells and of a borderline malignant ovarian cystadenoma. This finding verifies the postulated production of IGF BP‐1 by the human ovary. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：635 / 640

页数：6

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