MONOCLONAL-ANTIBODY-MEDIATED APOPTOSIS IN ADULT T-CELL LEUKEMIA

被引:154
作者
DEBATIN, KM
GOLDMANN, CK
BAMFORD, R
WALDMANN, TA
KRAMMER, PH
机构
[1] GERMAN CANC RES CTR,DIV IMMUNOGENET,W-6900 HEIDELBERG 1,GERMANY
[2] NCI,METAB BRANCH,BETHESDA,MD 20205
关键词
D O I
10.1016/0140-6736(90)90735-N
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The monoclonal antibody anti-APO-1 recognises a 52 kD cell membrane protein (APO-1) on some lymphoid tumour cell lines and on activated T cells. Binding of anti-APO-1 to cells expressing APO-1 results in programmed cell death, apoptosis, the most common form of death in eukaryotic cells. Expression of the antigen and sensitivity to the induction of cell death by anti-APO-1 were studied in human T-cell lines transformed by human leukaemia virus type 1 (HTLV-I) and in cultured cells from patients with adult T-cell leukaemia (ATL). APO-1 was strongly expressed on both types of cells and incubation of the cells with anti-APO-1 resulted in inhibition of proliferation and apoptosis. Induction of apoptosis may therefore be a possible therapeutic tool in HTLV-I-associated malignant disorders. © 1990.
引用
收藏
页码:497 / 500
页数:4
相关论文
共 14 条
[1]  
ARIMA N, 1986, BLOOD, V68, P779
[2]   T-CELL LYMPHOPROLIFERATIVE SYNDROME ASSOCIATED WITH HUMAN T-CELL LEUKEMIA LYMPHOMA VIRUS [J].
BRODER, S ;
BUNN, PA ;
JAFFE, ES ;
BLATTNER, W ;
GALLO, RC ;
WONGSTAAL, F ;
WALDMANN, TA ;
DEVITA, VT .
ANNALS OF INTERNAL MEDICINE, 1984, 100 (04) :543-557
[3]  
DEPPER JM, 1984, J IMMUNOL, V133, P1691
[4]   DEATH AND THE CELL [J].
DUVALL, E ;
WYLLIE, AH .
IMMUNOLOGY TODAY, 1986, 7 (04) :115-119
[5]   THE HUMAN INTERLEUKIN-2 RECEPTOR - NORMAL AND ABNORMAL EXPRESSION IN T-CELLS AND IN LEUKEMIAS INDUCED BY THE HUMAN T-LYMPHOTROPIC RETROVIRUSES [J].
GREENE, WC ;
LEONARD, WJ ;
DEPPER, JM ;
NELSON, DL ;
WALDMANN, TA .
ANNALS OF INTERNAL MEDICINE, 1986, 105 (04) :560-572
[6]   EVIDENCE FOR ABERRANT ACTIVATION OF THE INTERLEUKIN-2 AUTOCRINE LOOP BY HTLV-1-ENCODED P40X AND T3/TI COMPLEX TRIGGERING [J].
MARUYAMA, M ;
SHIBUYA, H ;
HARADA, H ;
HATAKEYAMA, M ;
SEIKI, M ;
FUJITA, T ;
INOUE, J ;
YOSHIDA, M ;
TANIGUCHI, T .
CELL, 1987, 48 (02) :343-350
[7]   ISOLATION OF A NEW TYPE-C RETROVIRUS (HTLV) IN PRIMARY UNCULTURED CELLS OF A PATIENT WITH SEZARY T-CELL LEUKEMIA [J].
POIESZ, BJ ;
RUSCETTI, FW ;
REITZ, MS ;
KALYANARAMAN, VS ;
GALLO, RC .
NATURE, 1981, 294 (5838) :268-271
[8]   DETECTION AND ISOLATION OF TYPE-C RETROVIRUS PARTICLES FROM FRESH AND CULTURED LYMPHOCYTES OF A PATIENT WITH CUTANEOUS T-CELL LYMPHOMA [J].
POIESZ, BJ ;
RUSCETTI, FW ;
GAZDAR, AF ;
BUNN, PA ;
MINNA, JD ;
GALLO, RC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (12) :7415-7419
[9]   ACTIVATION OF INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR (TAC) PROMOTER EXPRESSION BY THE TRANSACTIVATOR (TAT) GENE-PRODUCT OF HUMAN T-CELL LEUKEMIA-VIRUS, TYPE-I [J].
SIEKEVITZ, M ;
FEINBERG, MB ;
HOLBROOK, N ;
WONGSTAAL, F ;
GREENE, WC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5389-5393
[10]   TRANS-ACTING TRANSCRIPTIONAL ACTIVATION OF THE LONG TERMINAL REPEAT OF HUMAN T-LYMPHOTROPIC VIRUSES IN INFECTED-CELLS [J].
SODROSKI, JG ;
ROSEN, CA ;
HASELTINE, WA .
SCIENCE, 1984, 225 (4660) :381-385