A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-(-)-2-ACETYL-5,8-DIMETHOXY-1,2,3,4-TETRAHYDRO-2-NAPHTHOL - A KEY INTERMEDIATE IN THE SYNTHESIS OF ANTHRACYCLINONES

被引:30
作者
DAVIS, FA
KUMAR, A
CHEN, BC
机构
[1] Department of Chemistry, Drexel University, Philadelphia
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0040-4039(00)92107-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
AB-Synthon (R)-(-)-5, a key intermediate in the asymmetric synthesis of anthracyclinones 3 and 4 is prepared in 35% overall yield and > 95% ee. The key step involves hydroxylation of the potassium enolate of 7 using N-sulfonyloxaziridine (-)-6c.
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页码:867 / 870
页数:4
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