THEORETICAL ASPECTS OF CHIRAL SEPARATION IN CAPILLARY ELECTROPHORESIS .3. APPLICATION TO BETA-BLOCKERS

被引：173

作者：

WREN, SAC

ROWE, RC

机构：

[1] Pharmaceutical Department, ICI Pharmaceuticals, Macclesfield

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 635卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83120-H

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Enantiomers of the beta-blockers propranolol, atenolol, metoprolol, and oxprenolol have been separated by the addition of methyl-beta-cyclodextrin (MeBCD) to the operating buffer. There is an optimum concentration of MeBCD for separation for each of the beta-blockers, the magnitude of which could be ranked by the use of a mathematical model and log P data -an indication of the hydrophobicity of the molecule.

引用

页码：113 / 118

页数：6

共 18 条

[1]

COLE RO, 1990, HRC-J HIGH RES CHROM, V13, P579

[2] THE CLINICAL IMPORTANCE OF CARDIOSELECTIVITY AND LIPOPHILICITY IN BETA-BLOCKERS [J].

CRUICKSHANK, JM .

AMERICAN HEART JOURNAL, 1980, 100 (02) :160-178

[3]

DHULST A, 1992, HPCE 92

[4] USE OF CYCLODEXTRINS IN CAPILLARY ZONE ELECTROPHORESIS - RESOLUTION OF TERBUTALINE AND PROPRANOLOL ENANTIOMERS [J].

FANALI, S .

JOURNAL OF CHROMATOGRAPHY, 1991, 545 (02) :437-444

[5] SEPARATION OF OPTICAL ISOMERS BY CAPILLARY ZONE ELECTROPHORESIS BASED ON HOST GUEST COMPLEXATION WITH CYCLODEXTRINS [J].

FANALI, S .

JOURNAL OF CHROMATOGRAPHY, 1989, 474 (02) :441-446

[6] ELECTROKINETIC RESOLUTION OF AMINO-ACID ENANTIOMERS WITH COPPER(II) ASPARTAME SUPPORT ELECTROLYTE [J].

GOZEL, P ;

GASSMANN, E ;

MICHELSEN, H ;

ZARE, RN .

ANALYTICAL CHEMISTRY, 1987, 59 (01) :44-49

[7] USE OF COMPLEXING AGENTS FOR SELECTIVE SEPARATION IN HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS - CHIRAL RESOLUTION VIA CYCLODEXTRINS INCORPORATED WITHIN POLYACRYLAMIDE-GEL COLUMNS [J].

GUTTMAN, A ;

PAULUS, A ;

COHEN, AS ;

GRINBERG, N ;

KARGER, BL .

JOURNAL OF CHROMATOGRAPHY, 1988, 448 (01) :41-53

[8] CHIRAL SEPARATIONS BY HOST-GUEST COMPLEXATION WITH CYCLODEXTRIN AND CROWN-ETHER IN CAPILLARY ZONE ELECTROPHORESIS [J].

KUHN, R ;

STOECKLIN, F ;

ERNI, F .

CHROMATOGRAPHIA, 1992, 33 (1-2) :32-36

[9]

KUHN R, 1992, HPCE 92

[10]

Mayer S., 1992, J HIGH RES CHROMATOG, V15, P129, DOI DOI 10.1002/JHRC.1240150216

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