STEPWISE REGENERATION AND RECOVERY OF DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITE MONOMERS DURING SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS

被引：20

作者：

SCREMIN, CL

ZHOU, L

SRINIVASACHAR, K

BEAUCAGE, SL

机构：

[1] US FDA,CTR BIOL EVALUAT & RES,DIV HEMATOL PROD,BETHESDA,MD 20892

[2] US FDA,CTR DRUG EVALUAT & RES,DIV METAB & ENDOCRINE DRUG PROD,ROCKVILLE,MD 20857

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 08期

关键词：

D O I：

10.1021/jo00087a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deoxyribonucleoside phosphoramidites 1a-d have been regenerated, in a stepwise manner, during solid-phase oligonucleotide synthesis and have been efficiently reutilized in the solid-phase synthesis of polydeoxyribonucleotides. The activator 1H-tetrazole has also been recovered and recycled.

引用

页码：1963 / 1966

页数：4

共 38 条

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