PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA, INTERLEUKIN-1-ALPHA, AND INLERLEUKIN-6 DURING MURINE COCCIDIOIDOMYCOSIS

被引：19

作者：

COX, RA

MAGEE, DM

机构：

来源：

INFECTION AND IMMUNITY | 1995年 / 63卷 / 10期

关键词：

D O I：

10.1128/IAI.63.10.4178-4180.1995

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), and interleukin-6 (IL-6) were induced in mice infected with Coccidioides immitis. Analyses of the cytokine profiles of two inbred mouse strains which differ in their susceptibility to pulmonary challenge with C. immitis revealed higher levels of IL-6 in lungs from DBA/2 mice (resistant strain) than in those from BALB/c mice (susceptible strain) beginning at day 6 and continuing through day 15 postinfection. Spleen cells from both mouse strains secreted TNF-alpha, IL-1 alpha, and IL-6 in vitro in response to stimulation with killed spherules but differed in that spleen cells from the resistant strain produced increased levels of these cytokines earlier after pulmonary challenge and at increased levels throughout the course of the disease.

引用

页码：4178 / 4180

页数：3

共 22 条

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[2] IN-VITRO PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA BY ADHERENT HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS INCUBATED WITH KILLED COCCIDIOIDAL ARTHROCONIDIA AND SPHERULES [J].