LIPOPROTEIN (A) AND CORONARY HEART-DISEASE

被引：133

作者：

MAHER, VMG ^{[1
]}

BROWN, BG ^{[1
]}

机构：

[1] UNIV WASHINGTON,MED CTR,DEPT MED,DIV CARDIOL,SEATTLE,WA 98195

来源：

CURRENT OPINION IN LIPIDOLOGY | 1995年 / 6卷 / 04期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1097/00041433-199508000-00007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of lipoprotein (a) in the atherosclerotic process is continually being unraveled, and many of its potential proatherogenic and prothrombotic features have already been elucidated. Whereas most studies have demonstrated a strong association between lipoprotein (a) and the presence and severity of coronary heart disease, other groups have failed to observe such a relationship, which does question the importance of this particle in promoting atherosclerosis. Evidence from a study of human coronary atherosclerosis appears to demonstrate that the pathogenicity of lipoprotein (a) is modulated by concomitant LDL-cholesterol levels. Such a modulation of the pathogenicity of lipoprotein (a) may underlie the conflicting results regarding its association with coronary heart disease. This article will examine this possibility, and will also outline the potential mechanisms through which lipoprotein (a) may interact with LDL to exert its adverse effects. As a consequence of its interaction with LDL, alternative strategies for treating high levels of lipoprotein (a) will be discussed.

引用

页码：229 / 235

页数：7

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