2-AMINO-3-PHOSPHONOPROPIONATE BLOCKS THE INDUCTION AND MAINTENANCE OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL SLICES

被引：85

作者：

IZUMI, Y ^{[1
]}

CLIFFORD, DB ^{[1
]}

ZORUMSKI, CF ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 AUDUBON AVE,ST LOUIS,MO 63110

来源：

NEUROSCIENCE LETTERS | 1991年 / 122卷 / 02期

关键词：

HIPPOCAMPUS; LONG-TERM POTENTIATION; 2-AMINO-3-PHOSPHONOPROPIONATE; METABOTROPIC RECEPTOR;

D O I：

10.1016/0304-3940(91)90854-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rat hippocampal slices were used to examine the effects of 2-amino-3-phosphonopropionate (AP3), an inhibitor of phosphatidylinositol (PI) turn-over linked to metabotropic quisqualate receptors, on the development and maintenance of long-term potentiation (LTP) in area CAl. When perfused for 5 min prior to tetanization at concentrations of 100-1000-mu-M, D,L-AP3 had no effect on baseline synaptic transmission but blocked posttetanic potentiation (PTP) and the induction of LTP. Unlike the N-methyl-D-aspartate (NMDA) antagonists, 2-amino-5-phosphonovalerate (AP5) and MK-801, AP3 eliminated the late phase of LTP when applied immediately after tetanization. These data support the hypothesis that PI turnover is a factor in the expression and maintenance of LTP.

引用

页码：187 / 190

页数：4

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