CELLULAR-LOCALIZATION OF RAT ISK PROTEIN IN THE STRIA VASCULARIS BY IMMUNOHISTOCHEMICAL OBSERVATION

被引：86

作者：

SAKAGAMI, M

FUKAZAWA, K

MATSUNAGA, T

FUJITA, H

MORI, N

TAKUMI, T

OHKUBO, H

NAKANISHI, S

机构：

[1] OSAKA UNIV,SCH MED,DEPT ANAT,OSAKA,JAPAN

[2] KAGAWA MED SCH,DEPT OTOLARYNGOL,KAGAWA,JAPAN

[3] KYOTO UNIV,FAC MED,INST IMMUNOL,KYOTO 606,JAPAN

来源：

HEARING RESEARCH | 1991年 / 56卷 / 1-2期

关键词：

RAT ISK PROTEIN; POTASSIUM CHANNEL; MARGINAL CELL; STRIA VASCULARIS; IMMUNOHISTOCHEMISTRY;

D O I：

10.1016/0378-5955(91)90166-7

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

A novel rat membrane protein, termed I(sk) protein, that exhibits a voltage-dependent potassium channel activity was first reported through molecular cloning combined with an electrophysiological assay (Takumi et al., 1988). In the present study, we made an attempt to identify the cellular localization of the rat I(sk) protein in the stria vascularis using two types of antibodies that specifically react with the distinct parts of the rat I(sk) protein. Immunohistochemical analysis showed that the rat I(sk) protein was present only on the endolymphatic surface of the marginal cell. The possibility that the I(sk) protein is involved in potassium permeation in the luminal membrane of the marginal cell will be also discussed.

引用

页码：168 / 172

页数：5

共 20 条

[1] THE EFFECTS OF INHIBITION OF THE STRIAL NA+-K+-ACTIVATED ATPASE BY PERILYMPHATIC OUABAIN IN THE GUINEA-PIG [J].