MAGNESIUM AND KETAMINE ATTENUATE COGNITIVE DYSFUNCTION FOLLOWING EXPERIMENTAL BRAIN INJURY

被引：116

作者：

SMITH, DH

OKIYAMA, K

GENNARELLI, TA

MCINTOSH, TK

机构：

[1] Division of Neurosurgery, University of Pennsylvania, Philadelphia

来源：

NEUROSCIENCE LETTERS | 1993年 / 157卷 / 02期

关键词：

BRAIN INJURY; MEMORY; MAGNESIUM; KETAMINE; FLUID PERCUSSION;

D O I：

10.1016/0304-3940(93)90739-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluated the therapeutic effects of two noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, MgCl2 and ketamine, both individually and together, on cognitive dysfunction observed following parasagittal fluid-percussion (FP) brain injury in the rat. Using a modified Morris water maze technique, we found significant attenuation of post-traumatic memory dysfunction in animals treated with either MgCl2 (125 mumol) or ketamine (4 mg/kg) (P < 0.005). Combined MgCl2 and ketamine treatment also preserved memory function (P < 0.005), with no apparent additive effect.

引用

页码：211 / 214

页数：4

共 34 条

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[2]

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