ECONAZOLE, A BLOCKER OF CA2+ INFLUX, SELECTIVELY SUPPRESSES LTP OF EPSPS IN HIPPOCAMPAL SLICES

被引：5

作者：

FORGHANI, R ^{[1
]}

KRNJEVIC, K ^{[1
]}

机构：

[1] MCGILL UNIV,MCINTYRE CTR 1208,ANAESTHESIA RES DEPT,MONTREAL,PQ H3G 1Y6,CANADA

来源：

NEUROSCIENCE LETTERS | 1995年 / 196卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

RAT; LONG-TERM POTENTIATION; CA1 POPULATION SPIKES; CA RELEASE-ACTIVATED CA CURRENT;

D O I：

10.1016/0304-3940(95)11838-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Econazole - an agent that suppresses Ca2+ influx triggered by depletion of internal Ca-stores in non-excitable cells - was bath-applied to submerged slices from Sprague-Dawley rats. Econazole (15-20 mu M) had no consistent effect on afferent volleys, EPSPs or population spikes; but in seven out of nine slices, it prevented the induction of tetanic long-term potentiation (LTP) of field EPSPs. By contrast, all slices showed a marked LTP of population spikes. Ca2+ influx induced by tetanic depletion of Ca2+ stores may be essential for LTP of excitatory synaptic transmission.

引用

页码：122 / 124

页数：3

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