MINIREVIEW - TRICHOSANTHIN - A PROTEIN WITH MULTIPLE PHARMACOLOGICAL PROPERTIES

被引：80

作者：

SHAW, PC

CHAN, WL

YEUNG, HW

NG, TB

机构：

[1] CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG

[2] CHINESE UNIV HONG KONG,CHINESE MED MAT RES CTR,SHA TIN,HONG KONG

来源：

LIFE SCIENCES | 1994年 / 55卷 / 04期

关键词：

TRICHOSANTHIN; PLACENTA; ABORTION; IMMUNOMODULATION; HIV; TUMOR SUPPRESSION;

D O I：

10.1016/0024-3205(94)00727-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Trichosanthin (TCS), a protein isolated from the root tuber of the Chinese medicinal herb Trichosanthes kirilowii Maxim., is used to induce abortion in China, It also possesses immunomodulatory, anti-tumor and anti-human immunodeficiency virus properties. TCS is a member of the family of ribosome-inactivating proteins and inactivates eukaryotic ribosomes via its N-glycosidase activity. The gene encoding TCS has been cloned and over-expressed and the crystal structure of this protein resolved to 1.738 Angstrom. In this review, the various pharmacological properties of TCS are discussed and assessed.

引用

页码：253 / 262

页数：10

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