TURNING BEHAVIOR INDUCED BY INTRASTRIATAL INJECTION OF NEUROTENSIN IN MICE - SENSITIVITY TO NONPEPTIDE NEUROTENSIN ANTAGONISTS

被引:29
作者
PONCELET, M [1 ]
GUEUDET, C [1 ]
GULLY, D [1 ]
SOUBRIE, P [1 ]
LEFUR, G [1 ]
机构
[1] SANOFI RECH,DEPT NEUROPSYCHIAT,F-34184 MONTPELLIER 04,FRANCE
关键词
NEUROTENSIN-RECEPTOR; DOPAMINE; STRIATUM; TURNING-BEHAVIOR; MOUSE;
D O I
10.1007/BF00178206
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The intrastriatal injection of neurotensin (10 pg/mouse) elicited vigorous contralateral rotations which were not affected by disruption of dopaminergic transmission using 6-OHDA lesion of the striatum or systemic administration of spiroperidol (0.03 mg/kg). SR 48692, a selective non-peptide antagonist of neurotensin receptor, produced the following pattern of changes: a significant antagonism of rotations was observed at 0.04 and 0.08 mg/kg i.p. followed by a reinstatement of rotations at 0.16-0.64 mg/kg (at higher doses, a second antagonism occurred that lacked stereoselectivity). The reinstatement of rotations observed at 0.16 and 0.32 mg/kg of SR 48692 was abolished by spiroperidol and 6-OHDA lesions, suggesting the role of dopamine regulatory mechanisms.
引用
收藏
页码:57 / 60
页数:4
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