INVOLVEMENT OF BULBOSPINAL PATHWAYS IN THE ANTINOCICEPTIVE EFFECT OF CLOMIPRAMINE IN THE RAT

被引：31

作者：

ARDID, D

JOURDAN, D

MESTRE, C

VILLANUEVA, L

LEBARS, D

ESCHALIER, A

机构：

[1] FAC MED CLERMONT FERRAND,PHARMACOL MED LAB,EQUIPE NPPUA,F-63001 CLERMONT FERRAND,FRANCE

[2] INSERM,U161,F-75014 PARIS,FRANCE

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 02期

关键词：

ANTIDEPRESSANT DRUG; PAIN; DORSOLATERAL FUNICULUS; SEROTONIN;

D O I：

10.1016/0006-8993(95)00826-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was suppressed only in the hindpaw ipsilateral to the dorsolateral funiculus lesion, and suggest that the antinociceptive effect of antidepressants needs intact descending inhibitory bulbospinal pathways.

引用

页码：253 / 256

页数：4

共 15 条

[1] ANTINOCICEPTIVE EFFECTS OF ACUTE AND CHRONIC INJECTIONS OF TRICYCLIC ANTIDEPRESSANT DRUGS IN A NEW MODEL OF MONONEUROPATHY IN RATS [J].