Pathophysiology of Resistant Hypertension: The Role of Sympathetic Nervous System

被引：91

作者：

Tsioufis, Costas ^{[1
]}

Kordalis, Athanasios ^{[1
]}

Flessas, Dimitris ^{[1
]}

Anastasopoulos, Ioannis ^{[1
]}

Tsiachris, Dimitris ^{[1
]}

Papademetriou, Vasilios ^{[1
]}

Stefanadis, Christodoulos ^{[1
]}

机构：

[1] Univ Athens, Hippokrat Hosp, First Cardiol Clin, 3 Kolokotroni St, Athens 15236, Greece

来源：

INTERNATIONAL JOURNAL OF HYPERTENSION | 2011年 / 2011卷

关键词：

D O I：

10.4061/2011/642416

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Resistant hypertension (RH) is a powerful risk factor for cardiovascular morbidity and mortality. Among the characteristics of patients with RH, obesity, obstructive sleep apnea, and aldosterone excess are covering a great area of the mosaic of RH phenotype. Increased sympathetic nervous system (SNS) activity is present in all these underlying conditions, supporting its crucial role in the pathophysiology of antihypertensive treatment resistance. Current clinical and experimental knowledge points towards an impact of several factors on SNS activation, namely, insulin resistance, adipokines, endothelial dysfunction, cyclic intermittent hypoxaemia, aldosterone effects on central nervous system, chemoreceptors, and baroreceptors dysregulation. The further investigation and understanding of the mechanisms leading to SNS activation could reveal novel therapeutic targets and expand our treatment options in the challenging management of RH.

引用

页数：7

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