HETEROCYCLIC MESOIONIC STRUCTURES A NOVEL CLASS OF MONOAMINE OXIDASE INHIBITORS .1. ARYLSYDNONES

被引：18

作者：

CAMERON, DP

WISEMAN, EH

机构：

[1] Medical Research Laboratories, Chas. Pfizer & Co., Inc., Groton, Connecticut

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 04期

关键词：

D O I：

10.1021/jm00310a027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-arylsydnones (I) have been found to be noncompetitive inhibitors of the enzyme, monoamine oxidase. A reinterpretation of the mechanism of sydnone formation is discussed, as well as the mechanism of their noncompetitive inhibition of monoamine oxidase. It is believed that the sydnones fulfill many of the spatial and electronic requirements ascribed to the classical inhibitors although they are structurally unique to that family. © 1968, American Chemical Society. All rights reserved.

引用

页码：820 / &

共 24 条

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[2] AN ANTIMALARIAL ALKALOID FROM HYDRANGEA .11. SYNTHESIS OF 3-[BETA-KETO-GAMMA-(3-HYDROXYMETHYL-2-PYRROLIDYL AND 4-HYDROXYMETHYL-2-PYRROLIDYL)PROPYL]- 4-QUINAZOLONES [J].