THE MOLECULAR EVOLUTION OF ZFY-RELATED GENES IN BIRDS AND MAMMALS

被引:20
作者
LANFEAR, J [1 ]
HOLLAND, PWH [1 ]
机构
[1] UNIV OXFORD,DEPT ZOOL,MOLEC ZOOL LAB,OXFORD OX1 3PS,ENGLAND
关键词
DNA EVOLUTION; ZFY; DIVERGENCE; POLYMERASE CHAIN REACTION; SEX DETERMINATION; ZINC FINGERS;
D O I
10.1007/BF02102189
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report the isolation and nucleotide sequence determination of clones derived from five ZFY-related zinc-finger genes from birds and mammals. These sequences are analyzed with reference to the previously published human genes, ZFX and ZFY, and mouse genes, Zfx, Zfa, Zfy-1, and Zfy-2. The analysis indicates that ZFY-related genes are highly conserved in birds and mammals, and that the rate of nucleotide substitution in the Y-linked genes is not as high as predicted. However, the mouse Zfy-1 and Zfy-2 genes are markedly divergent members of the ZFY gene family; we suggest this relates to X-inactivation of the mouse gene Zfx.
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页码:310 / 315
页数:6
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