THE SYNTHESIS AND ANTIVIRAL PROPERTIES OF E-5-(2-BROMOVINYL)-4'-THIO-2'-DEOXYURIDINE

被引：64

作者：

DYSON, MR ^{[1
]}

COE, PL ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH CHEM,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 10期

关键词：

D O I：

10.1039/c39910000741

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical 7 step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside from 2-deoxy-D-ribose is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides which have potentially useful biological activity.

引用

页码：741 / 742

页数：2

共 9 条

[1] SYNTHESIS AND ANTIVIRAL PROPERTIES OF 5-VINYLPYRIMIDINE NUCLEOSIDE ANALOGS [J].

DECLERCQ, E ;

WALKER, RT .

PHARMACOLOGY & THERAPEUTICS, 1984, 26 (01) :1-44

[2]

DECLERCQ E, 1979, P NATL ACAD SCI USA, V76, P2947, DOI 10.1073/pnas.76.6.2947

[3] PHOSPHOROLYSIS OF (E)-5-(2-BROMOVINYL)-2'-DEOXYURIDINE (BVDU) AND OTHER 5-SUBSTITUTED-2'-DEOXYURIDINES BY PURIFIED HUMAN THYMIDINE PHOSPHORYLASE AND INTACT BLOOD-PLATELETS [J].

DESGRANGES, C ;

RAZAKA, G ;

RABAUD, M ;

BRICAUD, H ;

BALZARINI, J ;

DECLERCQ, E .

BIOCHEMICAL PHARMACOLOGY, 1983, 32 (23) :3583-3590

[4] ALTERNATIVE SYNTHESIS OF ANOMERIC METHYL 2-DEOXY-4-THIO-D-ERYTHRO-PENTOFURANOSIDES [J].

FU, YL ;

BOBEK, M .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (24) :3831-3834

[5]

FU YL, 1978, NUCLEIC ACID CHEM, P317

[6] NUCLEOTIDE SYNTHESIS .4. PHOSPHORYLATED 3'-AMINO-3'-DEOXYTHYMIDINE AND 5'-AMINO-5'-DEOXYTHYMIDINE AND DERIVATIVES [J].

GLINSKI, RP ;

KHAN, MS ;

KALAMAS, RL ;

SPORN, MB .

JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (25) :4299-4305

[7] NOVEL SYNTHESIS OF BENZYL 1,5-DITHIO-ALPHA-L-ARABINOPYRANOSIDES AND BETA-L-ARABINOPYRANOSIDES FROM 5-O-TOLUENE-PARA-SULPHONYL-L-ARABINOSSE DIBENZYL DITHIOACETAL [J].

HARNESS, J ;

HUGHES, NA .

JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (15) :811-&

[8] NUCLEOSIDES HAVING ACYCLIC 2-DEOXY-1-THIO-D-ARABINO-HEXITOL AND 2-DEOXY-1-THIO-D-ERYTHRO-PENTITOL CHAINS [J].

HORTON, D ;

MARKOVS, RA .

CARBOHYDRATE RESEARCH, 1980, 80 (02) :356-363

[9]

WALKER RT, 1978, SPECIAL PUBL, V4, pS103

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