EXPRESSION OF STRESS-RESPONSE (HEAT-SHOCK) PROTEIN-27 IN HUMAN BRAIN-TUMORS - AN IMMUNOHISTOCHEMICAL STUDY

被引：55

作者：

KATO, M

HERZ, F

KATO, S

HIRANO, A

机构：

[1] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DEPT PATHOL,111 E 210TH ST,BRONX,NY 10467

[2] ALBERT EINSTEIN COLL MED,MONTEFIORE MED CTR,DIV NEUROPATHOL,BRONX,NY 10467

来源：

ACTA NEUROPATHOLOGICA | 1992年 / 83卷 / 04期

关键词：

STRESS-RESPONSE PROTEIN; HEAT-SHOCK PROTEIN; BRAIN TUMORS; BREAST TUMOR METASTASES;

D O I：

10.1007/BF00713535

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This report concerns the expression of the low molecular weight stress-response (heat-shock) protein 27 (srp 27) in a variety of human brain tumors. Immunohistochemical techniques were used; cells of the breast cancer line MCF7 served as positive controls.The reaction product was found exclusively in the cytoplasm. Srp 27 was detected in 5/5 breast tumor metastases to the brain and in 5/21 meningiomas. The protein was also detected in 5/11 glioblastomas and 2/5 pituitary adenomas. By comparison, positive staining was observed in only 1/15 astrocytomas and 1/7 medulloblastoma and no reaction was seen with the oligodendrogliomas, schwannomas and gangliogliomas tested. These observations demonstrate that srp 27 is expressed by certain primary intracranial tumors.

引用

页码：420 / 422

页数：3

共 28 条

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