INTERFERON INHIBITS SYNAPTIC POTENTIATION IN RAT HIPPOCAMPUS

被引:51
作者
DARCANGELO, G
GRASSI, F
RAGOZZINO, D
SANTONI, A
TANCREDI, V
EUSEBI, F
机构
[1] IST REGINA ELENA,CTR RIC SPERIMENTALE,BIOFIS LAB,VIA MESSI ORO 156,I-00158 ROME,ITALY
[2] DIPARTIMENTO MED SPERIMENTALE COLLEMAGGIO,LAQUILA,ITALY
[3] UNIV ROMA TOR VERGATA,DIPARTIMENTO MED SPERIMENTALE & SCI BIOCHIM,ROME,ITALY
[4] UNIV ROME LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00185 ROME,ITALY
关键词
INTERFERON; LONG-TERM POTENTIATION; NEUROMODULATION; HIPPOCAMPUS; CA-CURRENT; N-METHYL-D-ASPARTATE RECEPTOR;
D O I
10.1016/0006-8993(91)91459-E
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of rat interferon (IFN) on the electrically-induced potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The treatment with rat IFN (120 U/ml) reduced the size of short-term potentiation (STP) and suppressed long-term potentiation (LTP). These IFN-induced effects were dose-dependent in the range of 50-500 U/ml. In addition, IFN slightly attenuated the potentiation when applied during the maintenance of LTP. Basal synaptic transmission was affected by IFN at concentrations greater-than-or-equal-to 250 U/ml. Following an acute exposure to IFN (500-2000 U/ml), cultured embryonic neurones from rat hippocampus often exhibited an attenuation of N-methyl-D-aspartate-induced currents and a variation (increase or decrease) of voltage-activated Ca2+ current amplitude. A possible role of IFN as neuromodulator in mammalian brain during immune responses is discussed.
引用
收藏
页码:245 / 248
页数:4
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