1-(SUBSTITUTED)BENZYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDES ARE POTENT ORALLY ACTIVE INHIBITORS OF TRYPANOSOMA-CRUZI IN MICE

被引：12

作者：

CHABALA, JC ^{[1
]}

WAITS, VB ^{[1
]}

IKELER, T ^{[1
]}

PATCHETT, AA ^{[1
]}

PAYNE, L ^{[1
]}

PETERSON, LH ^{[1
]}

REAMER, RA ^{[1
]}

HOOGSTEEN, K ^{[1
]}

WYVRATT, M ^{[1
]}

HANSON, WL ^{[1
]}

FISHER, MH ^{[1
]}

机构：

[1] UNIV GEORGIA,COLL VET MED,ATHENS,GA 30602

来源：

EXPERIENTIA | 1991年 / 47卷 / 01期

关键词：

1-(SUBSTITUTED)-BENZYL-5-AMINOIMIDAZOLE-4-CARBOXAMIDE; TRYPANOSOMA-CRUZI; CHAGAS DISEASE;

D O I：

10.1007/BF02041250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

1-(Substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi infections in mice. The most active compounds are the 1-(4-chlorobenzyl)- and 1-(3,4-dichlorobenzyl)-analogs (L-153,094 [2] and L-153,153 [4], resp.) which are approximately 7-fold more potent upon oral administration than nifurtimox (Lampit) in suppressing parasite levels in the blood of mice with acute Trypanosoma cruzi infections.

引用

页码：51 / 53

页数：3

共 10 条

[1]

Gamaliel B.A., 1969, GB Patent, Patent No. [GB1138529, 1138529, 1138529A]

[2] IMMUNIZATION OF MICE WITH IRRADIATED TRYPANOSOMA-CRUZI GROWN IN CELL-CULTURE - RELATION OF NUMBERS OF PARASITES, IMMUNIZING INJECTIONS, AND ROUTE OF IMMUNIZATION TO RESISTANCE [J].