X-INACTIVATION IN MAMMALIAN TESTIS IS CORRELATED WITH INACTIVE X-SPECIFIC TRANSCRIPTION

被引：138

作者：

RICHLER, C

SOREQ, H

WAHRMAN, J

机构：

[1] HEBREW UNIV JERUSALEM,DEPT GENET,IL-91904 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,DEPT BIOL CHEM,IL-91904 JERUSALEM,ISRAEL

来源：

NATURE GENETICS | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1038/ng1192-192

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

X chromosome inactivation occurs twice during the mammalian life cycle. In females one of the two X chromosomes of somatic nuclei is inactive, while in males the solitary X chromosome is inactivated during germ cell development. Despite the different properties of the inactivated chromosomes of females and males, the molecular initiation of inactivation may be the same. X inactive-specific transcripts, XIST, are produced from somatic inactivated X chromosomes. We demonstrate here the existence of XIST transcripts in testes of man and mouse. Inactivation of X chromosomes in males, as in females, may thus be mediated through XIST. Conceivably, the silencing of X-linked genes is the price paid for the evolution of successful mechanisms of chromosomal sex determination.

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页码：192 / 195

页数：4

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