LIPASE-CATALYZED ASYMMETRIC AND ENANTIOSELECTIVE ESTERIFICATION OF SPIRO[3.3]HEPTANES IN ORGANIC-SOLVENTS

被引：12

作者：

NAEMURA, K

FURUTANI, A

机构：

[1] Department of Chemistry, Faculty of Engineering Science, Osaka University, Toyonaka

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 11期

关键词：

D O I：

10.1039/p19910002891

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lipase-catalysed asymmetric esterification of 2,2,6,6-tetrakis(hydroxymethyl)spiro[3.3]heptane in both isopropyl ether and pyridine gave regiospecifically 2,6-bis(acetoxymethyl)-2,6-bis-(hydroxymethyl)spiro[3.3]heptane having axial chirality and moderate optical purity. Similarly, racemic diols of spiro compounds having axial chirality were resolved by lipase-catalysed enantioselective esterification in isopropyl ether.

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页码：2891 / 2892

页数：2

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