CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE, PRODUCED BY STREPTOMYCES-MELANOSPOROFACIENS MI614-43F2 - TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES

被引：28

作者：

AOYAGI, T ^{[1
]}

AOYAMA, T ^{[1
]}

KOJIMA, F ^{[1
]}

HATTORI, S ^{[1
]}

HONMA, Y ^{[1
]}

HAMADA, M ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI,MACHIDA,TOKYO 194,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 10期

关键词：

D O I：

10.7164/antibiotics.45.1587

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyclooctatin has been isolated from Streptomyces melanosporofaciens M1614-43F2 as part of a program designed to find microorganism-produced inhibitors of lysophospholipase. It was purified by chromatography on silica gel, Capcell Pak C18 (HPLC) and Sephadex LH-20 followed by solvent extraction and then isolated as a colorless powder. Cyclooctatin has the molecular formula of C20H34O3. It is competitive with the substrate, and the inhibition constant (Ki) was 4.8 x 10(-6) M.

引用

页码：1587 / 1591

页数：5

共 8 条

[1] THE STRUCTURE OF CYCLOOCTATIN, A NEW INHIBITOR OF LYSOPHOSPHOLIPASE [J].