NOTES ON THE ASSESSMENT OF TREND IN THE PRESENCE OF NONDIFFERENTIAL EXPOSURE MISCLASSIFICATION

被引：10

作者：

BRENNER, H

机构：

[1] Unit of Epidemiology, University of Ulm, Am Hochsträss 8, Ulm

来源：

EPIDEMIOLOGY | 1992年 / 3卷 / 05期

关键词：

EPIDEMIOLOGIC METHODS; MISCLASSIFICATION; STATISTICS;

D O I：

10.1097/00001648-199209000-00007

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Estimation of overall linear trend and statistical tests for trend are commonly applied in epidemiologic studies to evaluate the association between ordinal exposure variables and dichotomous health outcomes. In the discussion of these studies, the assertion is commonly made that the observed trends can only be conservative and reported P-values can only be too high owing to the occurrence of exposure misclassification that is supposed to be nondifferential, that is, unrelated to the health outcome of interest. This paper illustrates that this assertion is not generally justified without additional sensitivity analyses. Overestimation of trends and an erroneous reduction of P-values due to nondifferential exposure misclassification are unlikely, but not impossible, for monotonic exposure-disease associations. These may be common occurrences, however, if the observed exposure-disease association is nonmonotonic.

引用

页码：420 / 427

页数：8

共 38 条

[1]

Bross I., Misclassification in 2 x 2 tables, Biometrics, 10, pp. 478-484, (1954)

[2]

Copeland K.T., Checkowav H., Holbrook R.H., McMichael A.J., Bias due to misclassification in the estimate of relative risk, Am J Epidemiol, 105, pp. 488-495, (1977)

[3]

Gladen B., Rogan W.J., Misclassification and design of environmental studies, Am J Epidemiol, 109, pp. 607-616, (1979)

[4]

Walker A.M., Velema J.P., Robins J.M., Analysis of case-control data derived in part from proxy respondents, Am J Epidemiol, 127, pp. 905-914, (1988)

[5]

Dosemeci M., Wacholder S., Lubin J.H., Does nondifferential misclassification of exposure always bias a true effect toward the null value, Am J Epidemiol, 132, pp. 746-748, (1990)

[6]

Brenner H., Re: Does nondifferential misclassification of exposure always bias a true effect toward the null value, Am J Epidemiol, 134, pp. 438-439, (1991)

[7]

Dosemeci M., Wacholder S., Lubin J.H., Re: Does nondifferential misclassification of exposure always bias a true effect toward the null value, Am J Epidemiol, 134, pp. 441-442, (1991)

[8]

Breslow N.E., Day N.E., Statistical Methods in Cancer Research, (1987)

[9]

Mote V.L., Anderson R.L., An investigation of the effect of misclassification on the properties of y-tests in the analysis of categorical data, Biometrika, 52, pp. 95-109, (1965)

[10]

Assakul K., Proctor C.H., Testing independence in two-way contingency tables with data subject to misclassification, Psychometrika, 32, pp. 67-76, (1967)

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