SYNTHESIS AND PHYSICOCHEMICAL STUDY OF COLLAGEN HYDROPHOBIC DERIVATIVES

被引：9

作者：

FONSECA, MJ ^{[1
]}

BUSQUETS, MA ^{[1
]}

ALSINA, MA ^{[1
]}

REIG, F ^{[1
]}

机构：

[1] PHYSICOCHEM UNITY,DEPT PHARM,BARCELONA,SPAIN

来源：

LANGMUIR | 1993年 / 9卷 / 11期

关键词：

D O I：

10.1021/la00035a066

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lauryl, hexyl, and succinoyl derivatives of collagen have been synthesized using lauryl/hexyl aldehydes and succinic anhydride as reactants. After chemical characterization, the physicochemical properties of these three collagen derivatives as well as those of the native protein have been studied. The techniques used were ANS and CF fluorescence, surface activity, and surface interaction with monomolecular layers of phospholipids. Hydrophobicity values of these preparations do not follow the expected order according to their substituents. Lauryl collagen shows a break point in its surface activity, indicative of the presence of aggregation.

引用

页码：3149 / 3153

页数：5

共 10 条

[1]

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[2] LIPOSOMAL STABILIZATION OF CAMPTOTHECINS LACTONE RING [J].