EICOSANOIDS FROM THE TROPICAL RED-ALGA MURRAYELLA-PERICLADOS

被引：21

作者：

BERNART, MW ^{[1
]}

GERWICK, WH ^{[1
]}

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

来源：

PHYTOCHEMISTRY | 1994年 / 36卷 / 05期

关键词：

MURRAYELLA PERICLADOS; RHODOMELACEAE; RED ALGAE; 12-HETE; HEPOXILIN B; EPOXYALCOHOL; (6E)-LEUKOTRIENE B-4; OXYLIPIN; 12-LIPOXYGENASE;

D O I：

10.1016/S0031-9422(00)89643-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid extracts of several collections of the tropical red marine alga Murrayella periclados were found to be rich sources of eicosanoids more commonly associated with mammalian systems, including 12S-hydroxyeicosapentaenoic acid, 12S-hydroxyeicosaletraenoic acid, (6E)-leukotriene B-4, and erythro and three diastereomers of hepoxilins B-3 and B-4. This is the first report of leukotriene or hepoxilin B-4 natural products from a plant, and several spectroscopic features of these molecules are reported herein for the first time, Two conjugated triene-containing acids recently reported from another red alga, 5Z,7E,9E,14Z,17Z-eicosapentaenoic acid and 5E,7E,9E,14Z,17Z-eicosapentaenoic acid, were also found in the algal extract. A 12-lipoxygenase initiated biosynthetic origin is proposed for most of these Murrayella oxylipins.

引用

页码：1233 / 1240

页数：8

共 44 条

[1]

ANDERSEN NH, 1969, J LIPID RES, V10, P316

[2] ANTIBIOTIC-ACTIVITY OF LIPID-SOLUBLE EXTRACTS FROM CARIBBEAN MARINE-ALGAE [J].