HIGH-DOSE CHLORAMBUCIL AND DEXAMETHASONE FOR RELAPSED NON-HODGKINS-LYMPHOMAS

被引：6

作者：

JOSEPH, G ^{[1
]}

HADLEY, T ^{[1
]}

DJULBEGOVIC, B ^{[1
]}

HAMM, J ^{[1
]}

SEEGER, J ^{[1
]}

BLUMENREICH, M ^{[1
]}

WOODCOCK, T ^{[1
]}

机构：

[1] UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DIV MED ONCOL,LOUISVILLE,KY 40202

来源：

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1993年 / 16卷 / 04期

关键词：

CHLORAMBUCIL; DEXAMETHASONE; LYMPHOMA; RELAPSED LYMPHOMA; NON-HODGKINS LYMPHOMA;

D O I：

10.1097/00000421-199308000-00008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty patients with relapsed or refractory non-Hodgkin's lymphoma were treated with high-dose chlorambucil (14 mg/m2 every 6 hours for 6 doses) and dexamethasone (40 mg/day for 5 days). There was a 45% response rate with 17% complete responses. The median duration of complete response was 7 months. The regimen was well tolerated and had minimal toxicity.

引用

页码：319 / 322

页数：4

共 9 条

[1]

ALEXANIAN R, 1986, ANN INTERN MED, V105, P8, DOI 10.7326/0003-4819-105-1-8

[2] EFFECTIVE TREATMENT OF ADVANCED MULTIPLE-MYELOMA REFRACTORY TO ALKYLATING-AGENTS [J].

BARLOGIE, B ;

SMITH, L ;

ALEXANIAN, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (21) :1353-1356

[3] A PHASE-I TRIAL OF CHLORAMBUCIL ADMINISTERED IN SHORT PULSES IN PATIENTS WITH ADVANCED MALIGNANCIES [J].

BLUMENREICH, MS ;

WOODCOCK, TM ;

SHERRILL, EJ ;

RICHMAN, SP ;

GENTILE, PS ;

EPREMIAN, BE ;

KUBOTA, TT ;

ALLEGRA, JC .

CANCER INVESTIGATION, 1988, 6 (04) :371-375

[4]

CADMAN E, 1982, CANCER, V50, P1037, DOI 10.1002/1097-0142(19820915)50:6<1037::AID-CNCR2820500603>3.0.CO

[5]

2-N

[6] A PHASE-II TRIAL OF INTERMITTENT LEUKOCYTE INTERFERON AND HIGH-DOSE CHLORAMBUCIL IN THE TREATMENT OF NON-HODGKINS LYMPHOMA RESISTANT TO CONVENTIONAL THERAPY [J].

CLARK, RH ;

DIMITROV, NV ;

AXELSON, JA ;

CHARAMELLA, LJ ;

STOTT, PB .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1989, 12 (01) :75-77

[7] ACTIVITY OF FLUDARABINE IN PREVIOUSLY TREATED NON-HODGKINS LOW-GRADE LYMPHOMA - RESULTS OF AN EASTERN COOPERATIVE ONCOLOGY GROUP-STUDY [J].

HOCHSTER, HS ;

KIM, K ;

GREEN, MD ;

MANN, RB ;

NEIMAN, RS ;

OKEN, MM ;

CASSILETH, PA ;

STOTT, P ;

RITCH, P ;

OCONNELL, MJ .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (01) :28-32

[8] 2-CHLORODEOXYADENOSINE TREATMENT OF LOW-GRADE LYMPHOMAS [J].

KAY, AC ;

SAVEN, A ;

CARRERA, CJ ;

CARSON, DA ;

THURSTON, D ;

BEUTLER, E ;

PIRO, LD .

JOURNAL OF CLINICAL ONCOLOGY, 1992, 10 (03) :371-377

[9]

VELASQUEZ WS, 1988, BLOOD, V71, P117

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