HELICOBACTER-PYLORI-ASSOCIATED GASTRITIS - EVOLUTION OF HISTOLOGIC-CHANGES OVER 10 YEARS

被引:47
作者
NIEMELA, S [1 ]
KARTTUNEN, T [1 ]
KEROLA, T [1 ]
机构
[1] OULU UNIV HOSP,DEPT PATHOL,SF-90220 OULU,FINLAND
关键词
FOLLOW-UP; GASTRITIS; HELICOBACTER PYLORI;
D O I
10.3109/00365529509089787
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Helicobacter pylori seems to be the commonest cause of chronic gastritis, but the natural course of H. pylori-associated gastritis is largely obscure. Methods: We present a histologic follow-up of 39 patients with H. pylori-positive gastritis. Gastroscopies with stepwise biopsies were performed in air the patients at an interval of 10 years. Results: Of the patients 87% (34/39) had a persistent infection and showed a significant decrease in the grades of antral gastritis, eosinophilic granulocytes, corpus eosinophilic granulocytes, and foveolar hyperplasia and a significant increase in the grade of corpus neutrophilic granulocytes. The quantities of H. pylori as estimated histologically did not change significantly during the follow-up period in patients with a persistent infection. In the five other patients (13%) the H. pylori infection had apparently disappeared spontaneously, and this was accompanied by decreases in the amount of inflammatory cells in the gastric mucosa. Conclusions: H. pylori infection in the gastric mucosa is chronic and may be associated with both regressive and progressive histologic changes. Spontaneous healing of H. pylori infection is possible and is associated with partial resolution of the inflammatory changes in the gastric mucosa.
引用
收藏
页码:542 / 549
页数:8
相关论文
共 23 条
  • [1] BASOPHIL-BOUND AND SERUM IMMUNOGLOBULIN-E DIRECTED AGAINST HELICOBACTER-PYLORI IN PATIENTS WITH CHRONIC GASTRITIS
    ACETI, A
    CELESTINO, D
    CAFERRO, M
    CASALE, V
    CITARDA, F
    CONTI, EM
    GRASSI, A
    GRILLI, A
    PENNICA, A
    SCIARRETTA, F
    LERI, O
    AMEGLIO, F
    SEBASTIANI, A
    [J]. GASTROENTEROLOGY, 1991, 101 (01) : 131 - 137
  • [2] Correa P, 1988, CANCER RES, V48, P1319
  • [3] INTESTINAL METAPLASIA, NOT ATROPHY OR ACHLORHYDRIA, CREATES A HOSTILE ENVIRONMENT FOR HELICOBACTER-PYLORI
    GENTA, RM
    GRAHAM, DY
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1993, 28 (10) : 924 - 928
  • [4] GRAANEN ME, 1992, GUT, V33, P16
  • [5] LONG-TERM HISTOLOGIC CONSEQUENCES OF SUPPRESSION ERADICATION OF HELICOBACTER-PYLORI IN ANTRAL MUCOSA
    JASKIEWICZ, K
    LOUW, JA
    MARKS, IN
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1993, 5 (09) : 701 - 705
  • [6] HELICOBACTER-PYLORI IN DYSPEPTIC PATIENTS - QUANTITATIVE ASSOCIATION WITH SEVERITY OF GASTRITIS, INTRAGASTRIC PH, AND SERUM GASTRIN-CONCENTRATION
    KARTTUNEN, T
    NIEMELA, S
    LEHTOLA, J
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 : 124 - 134
  • [7] KARTTUNEN T, 1987, SCAND J GASTROENTERO, V22, P478
  • [8] Keenan D.R, 1990, WATSONS BAY LINE SYD
  • [9] GRADE OF HELICOBACTER-PYLORI COLONIZATION IN RELATION TO GASTRITIS - A 6-YEAR POPULATION-BASED FOLLOW-UP-STUDY
    KEKKI, M
    MAAROOS, HI
    SIPPONEN, P
    UIBO, R
    TAMMUR, R
    TAMM, A
    VILLAKO, K
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1991, 26 : 142 - 150
  • [10] SEROCONVERSION FOR HELICOBACTER-PYLORI
    KUIPERS, EJ
    PENA, AS
    VANKAMP, G
    UYTERLINDE, AM
    PALS, G
    PELS, NFM
    KURZPOHLMANN, E
    MEUWISSEN, SGM
    [J]. LANCET, 1993, 342 (8867) : 328 - 331