CLOZAPINE TREATMENT OF SCHIZOPHRENIC-PATIENTS - PLASMA CONCENTRATION AND COAGULATION-FACTORS

被引：40

作者：

THORUP, M ^{[1
]}

FOG, R ^{[1
]}

机构：

[1] ST HANS HOSP, DEPT E, DK-4000 ROSKILDE, DENMARK

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1977年 / 55卷 / 02期

关键词：

D O I：

10.1111/j.1600-0447.1977.tb00148.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Male chronic schizophrenic hospitalized patients (11), treated with a constant dose of clozapine (200-600 mg daily) as their only neuroleptic medication, were studied for a long period of time (minimum 12 wk). Wide variations in the plasma concentration of clozapine were found in different patients who received the same oral dose, as well as great changes from week to week in the individual patient given a constant dose. The plasma levels of clozapine appeared to have no correlation with either the clinical effect or the side effects. No differences with regard to coagulation factors were found between the patients and the controls.

引用

页码：123 / 126

页数：4

共 13 条

[1]

ANGST J, 1974, SOMATISCHE THERAPIE, P93

[2] INCREASED PLATELET-AGGREGATION RESPONSES TO 5-HYDROXYTRYPTAMINE IN PATIENTS TAKING CHLORPROMAZINE [J].