METASTATIC HETEROGENEITY OF HUMAN RENAL-CELL CARCINOMA

被引：3

作者：

NAITO, S

KUMAZAWA, J

VONESCHENBACH, AC

FIDLER, IJ

机构：

[1] Department of Urology, Kyushu University, Fukuoka

[2] Departments of Urology, University of Texas System Cancer Center, MD Anderson Hospital and Tumor Institute, Houston, TX

[3] Departments of Cell Biology, University of Texas System Cancer Center, MD Anderson Hospital and Tumor Institute, Houston, TX

来源：

UROLOGIA INTERNATIONALIS | 1991年 / 47卷

关键词：

HUMAN RENAL CELL CARCINOMA; METASTASIS; HETEROGENEITY; NUDE MOUSE;

D O I：

10.1159/000282262

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The demonstration that cancers are biologically heterogeneous has a far-reaching implication for therapy. We reviewed recent data from our laboratories that deal with metastatic heterogeneity of human renal cell carcinoma (HRCC) and with the development of nude mouse model for studying HRCC metastasis. The SN12C HRCC line contained heterogeneous subpopulations of cells with different metastatic potential and cells derived from spontaneous lung metastases were, in general, more metastatic than cells of the SN12C parental line. Nude mice were useful to select such variants with high metastatic potential. Our model for HRCC permits a better understanding of the complexity of the process of tumor evolution, progression and metastasis.

引用

页码：90 / 95

页数：6

共 20 条

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