SUSCEPTIBILITY OF PNEUMOCYSTIS-CARINII TO ARTEMISININ INVITRO

被引：41

作者：

MERALI, S ^{[1
]}

MESHNICK, SR ^{[1
]}

机构：

[1] CUNY CITY COLL,DEPT MICROBIOL,138TH ST & CONVENT AVE,NEW YORK,NY 10031

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 06期

关键词：

D O I：

10.1128/AAC.35.6.1225

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The susceptibility of Pneumocystis carinii to artemisinin (qinghaosu) was determined in short-term primary culture. In untreated cultures, trophozoites increased an average of fivefold over 4 days. Inhibition of parasite growth in cultures treated with artemisinin at concentrations as low as 0.5-mu-M was seen. In contrast, artemisinin concentrations up to 100-mu-M had no effect on feeder layer cells.

引用

页码：1225 / 1227

页数：3

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