ANTIHYPERTENSIVE DRUG EFFECTS ON PLACENTAL FLOW VELOCITY WAVE-FORMS IN PREGNANT-WOMEN WITH SEVERE HYPERTENSION

被引：21

作者：

DUGGAN, PM

MCCOWAN, LME

STEWART, AW

机构：

[1] Department of Obstetrics and Gynaecology, National Women's Hospital

[2] Department of Community Medicine, School of Medicine, University of Auckland

来源：

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY | 1992年 / 32卷 / 04期

关键词：

D O I：

10.1111/j.1479-828X.1992.tb02846.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Doppler studies of the uterine and umbilical arteries were performed in 24 acutely hypertensive pregnant women. Women were divided into 2 groups: Group 1 (diastolic blood pressure (DBP) > 110 mm Hg) received placebo (n = 6) or 10 mg oral nifedipine (n = 9); Group 2 (DBP greater-than-or-equal-to 110 mm Hg) received 10 mg oral nifedipine (n = 5) or 10 mg intravenous hydralazine (n = 4). Treatment allocations were random within groups and the investigator and patient were blind to the treatments. Baseline flow velocity waveforms (FVW) and posttreatment FVW's at 30, 60 and 120 minutes were recorded. There was no significant difference between baseline and posttreatment FVW indices within or between groups. Placebo was as effective as nifedipine in lowering blood pressure over 2 hours of study. There were no significant adverse effects of treatment.

引用

页码：335 / 338

页数：4

共 11 条

[1]

Gant NF, Pritchard JA., The management of severe hypertension in pregnancy, from Hypertension in Pregnancy, Proceedings of the Sixteenth Study Group of the Royal College of Obstetricians & Gynaecologists, pp. 361-378, (1986)

[2]

Redman CWG, Beilin LJ, Bonnar J., Treatment of Hypertension in Pregnancy with Methyldopa: Blood Pressure Control and Side‐Effects, Br J Obstet Gynecol, 84, pp. 419-426, (1977)

[3]

Davey DA, MacGillivray I., The classification and definition of the hypertensive disorders in pregnancy, Hypertension in Pregnancy, Proceedings of the Sixteenth Study Group of the Royal College of Obstetricians and Gynaecologists, pp. 401-409, (1986)

[4]

Pearce JM, Campbell S., Cohen-Overbeek T., Hackett G., Hernandez J., Royston JP., Reference ranges and sources of variation for indices of pulsed Doppler flow velocity waveforms from the uteroplacental and fetal circulation, Br J Obstet Gynaecol, 95, pp. 248-256, (1988)

[5]

Krebs H-B, Petres RE., Clinical application of a scoring system for evaluation of antepartum fetal heart rate monitoring, Am J Obstet Gynecol, 130, pp. 765-771, (1978)

[6]

Hunyor SN, Flynn JM, Cochineas C., Comparison of performance of various sphygmomanometers with intra‐arterial biood‐pressure readings, BMJ, 15, pp. 159-162, (1978)

[7]

Brinkman CR, Assali NS., Uteroplacental Hemodynamic Response to Antihypertensive Drugs in Hypertensive Sheep, from Hypertension in Pregnancy, pp. 363-375, (1976)

[8]

Doyle AE., Response to Placebo Treatment in Hypertension, Hypertension, 5, pp. 1113-1114, (1983)

[9]

Hossmann V., FitzGerald GA, Dollery CT., Influence of Hospitalisation and Placebo Therapy on Blood Pressure and Sympathetic Function in Essential Hypertension, Hypertension, 3, pp. 113-118, (1981)

[10]

Lindow SW, Davies N., Davey DA, Smith JA., The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy, Br J Obstet Gynaecol, 95, pp. 1276-1281, (1988)

← 1 2 →